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Gamma secretase inhibitor hearing loss

Gamma secretase inhibitor hearing loss

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Figure 3

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By clipping these cell membrane proteins into smaller pieces, gamma- secretase helps the cell transport cellular material from one side of the cell membrane ...

Functional and histological damage in guinea pig cochleae by noise exposure. A: ABR threshold

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Comparison of hair cell numbers in left and right ears of animals matched ABR criteria for

The drug caused peaks of complete inhibition alternating with full enzyme activity, rather than a more desirable partial but chronic inhibition, ...

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REgeneration of inner ear hair cells with GAmma-secretase INhibitors

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Drug being tested in London could be breakthrough in treating hearing loss

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Frequency Therapeutics Develops Small-Molecule Drugs to Treat Hearing Loss

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Regeneration in Birds

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Figure 3 Overview of the mechanisms of cochlear injury in noise-induced hearing loss and interventions. HPA: Hypothalamic-pituitary-adrenal; ...

Figure 2

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Sound Science | April 7, 2014 Issue - Vol. 92 Issue 14 | Chemical & Engineering News

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Treatment of inner ear stem cells with a γ -secretase inhibitor increased conversion to

Overview of the mechanisms of cochlear injury in noise-induced hearing loss and interventions.

Figure 2 Mechanism of oxidative cellular damage. Mechanism of oxidative cellular damage. Reactive oxygen species (ROS, including superoxide anion, O2·-, ...

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Now, scientists are testing new drugs that could banish hearing aids for good for the

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Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma - ScienceDirect

Clinical trials employing γ-secretase inhibitors in the treatment of breast cancer

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Hearing Help

Notch pathway inhibitor; Inhibits γ-secretase. LY411575

Addressing Hearing Loss with Stem Cells - Organ of Corti cultured for 48 hours in the

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Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles | Scientific ...

Canonical Notch signaling plays an instructive role in auditory supporting cell development | Scientific Reports

Therapeutic potential of a gamma-secretase inhibitor for hearing restoration in a guinea pig model with noise-induced hearing loss.

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Effect of APP γ -secretase inhibition on proliferation of trisomic neural precursor cells. Neural

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Figure 6

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Inhibition of γ -secretase increased hair cell differentiation by upregulating Math1

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Treatment injected into ear could restore hearing. (Photo: Pixabay)

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Representational Image. (Photo: Pexels)

Inhibition of gamma-Secretase Activity Inhibits Tumor Progression.

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Effect of APP γ -secretase inhibition on differentiation of trisomic neural precursor cells. NPCs

Frequency Therapeutics Develops Small-Molecule Drugs to Treat Hearing Loss

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Download figure · Open in new tab · Download powerpoint. Figure 2. Effect of γ-secretase inhibitors ...

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Chemical structure of γ-secretase inhibitors … Significant components in the Notch signaling pathway. Abbreviations: ADAM/TACE, a disintegrin

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Kiyomi Hamaguchi

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Our Consortium

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... with severe hearing loss increasing that risk to five times. As a result, it is urgent that new hearing therapies are developed and made available to ...

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Eli Lilly and Company

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The National and Kapodistrian University of Athens

University of Tübingen

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a, Schematic of vestibular end organs and type I/II vestibular hair cells.

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The Notch pathway. Notch is synthesised as a precursor protein that is processed by a

Analysis of P0 and P5 supporting cells response to Notch inhibition.

Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21 | Nature Immunology

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Presenilin allele consequences

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